Symbol
Name
ID

Il2rb
interleukin 2 receptor, beta chain
MGI:96550

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgG level

Autoimmune hemolytic anemia

Decreased CD4:CD8 ratio

Persistent CMV viremia

Lymphadenopathy

Thymoma

Splenomegaly

Recurrent otitis media

Recurrent urinary tract infections

Abnormality of the immune system

Autoimmunity

Immunodeficiency

Asthma

Recurrent respiratory infections

Disease(s) Associated with IL2RB

asthma

immunodeficiency 63

myasthenia gravis

Mouse Phenotypes

decreased T cell proliferation

thymus hypoplasia

enlarged spleen

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T cell clonal deletion

decreased double-positive T cell number

increased susceptibility to autoimmune hemolytic anemia

increased neutrophil cell number

increased granulocyte number

increased plasma cell number

decreased B cell number

decreased NK cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased NK T cell number

decreased memory T cell number

decreased regulatory T cell number

increased activated T cell number

abnormal mononuclear cell morphology

abnormal lymphocyte morphology

abnormal marginal zone B cell morphology

abnormal T cell morphology

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal B cell activation

increased IgE level

increased IgG1 level

increased IgM level

abnormal T cell activation

abnormal immune system organ morphology

enlarged lymph nodes

increased anti-nuclear antigen antibody level

increased anti-double stranded DNA antibody level

liver inflammation

abnormal response to transplant

Availability

Mouse Genotype

Il2rb^m1Btlr/Il2rb^m1Btlr

Il2rb^m2Btlr/Il2rb^m2Btlr

Il2rb^M3Btlr/Il2rb^M3Btlr

Il2rb^tm1Mak/Il2rb^tm1Mak

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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